Eurofins Clinical Genetics >> Genetic Services >> ArraySure | CGH

ArraySure | CGH

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Approximately 60–70% of first-trimester miscarriages are caused by chromosomal abnormalities, including aneuploidies, triploidy, uniparental disomy (UPD), etc. Traditional cytogenetic analysis of these samples is frequently challenging due to high rates of culture failure and maternal contamination, increasing the turnaround time for the results.ArraySure is optimized for balanced whole-genome coverage, enabling high-resolution DNA copy number analysis with precise breakpoint accuracy as well as high-density SNP coverage for loss of heterozygosity (LOH) / absence of heterozyosity (AOH), long contiguous stretch of  homozygosity (LCSH), and uniparental isodisomy (UPD) detection.

ArraySure enables low-level mosaicism visualization, absence of heterozygosity (AOH) and acquired UPD (aUPD) detection, copy number change confirmation, triploidy detection, allelic imbalance pattern visualization.

ArraySure® Optima

  • ArraySure® Optima is designed as a robust and cost-effective array with streamlined analysis of your prenatal and miscarriage products of conception (POC) samples.
  • It consists of a total of 315,608 features covering control, copy number (CN), and single-nucleotide polymorphism (SNP) probes.
  • Total of 18,018 CN and 148,450 SNP markers uniformly spaced over the genome with enhanced interrogation of 396 regions of prenatal interest.
  • A minimum resolution of 1 MB for losses, 2 MB for gains, and 5 MB for LOH/AOH
  • Increased coverage density (25 markers/100 kb) in 396 empirically selected regions relevant for prenatal research
  • Faster TAT of 20 working days

 

Functional Resolution Coverage

ArraySure® Optima

Intergenic (noncoding regions)

>500Kb \ (at least 1Mb for Losses and 2 Mb for Gains)

ISCA

>400 Kb

OMIM

>400 Kb

Refseq

>400 Kb

Cancer

>400 Kb

X-Chr OMIM

>400 Kb

Prenatal Empirical List

100 Kb

Loss of Heterozygosity (LOH)

≥5 Mb

Mosaic Detection

>20%

* Functional Resolution based on 25 markers. Coverage based on 100kb genomic distance.

Sample Requirement

  1. 20 ml Amniotic Fluid /CVS
  2. 20 mg Tissue Biopsy
  3. 5 ml of Blood / Buccal Swab